AAPS 2010 National Biotechnology Conference May 16, 2010

Abstract by Ziping Wei, Fellow will be presented on comparability assessment of biopharmaceutical products: strategy and practice.

Abstract by Inna Vainshtein, Scientist II, Mojica, Mehrzai, Roskos and Liang will be presented on the development and validation a cell based assay for detection of neutralizing antibodies against MEDI 573, a therapeutic antibody against insulin-like growth factors l and II.

Poster by Suzanne Hudak, Associate Scientist I, T. Leach, N. Jee and B. Domigan on the effects of surface tension and excipient binding on the conformational stabilization of a monoclonal antibody.

Poster by Carlos Chavez, Associate Scientist II, A. Schneider, R. Faggioni and M. Liang on the quantitation of MEDI 5117, a fully human monoclonal antibody against IL-6, in human serum.

Poster by Shufeng Bai, Research Associate II, Hasige Sathish an dAmbarish S on the role of inter-domain interactions in reversible self association of a full length monoclonal antibody.

Poster by Rozanne Lee, Scientist I, Rafaella Faggioni, T. Scott Manetz, Lorin Roskos and Meina Liang on the development and qualification of IL-6 assay as pharmacodynamic biomarker for MEDI 5117, a fully human monoclonal antibody to human IL-6.

Presentation by Mariana Dimitrova, Senior Scientist and Steven Bishop on the formulation strageties in the development of PFS presentations of high-concentration monoclonal antibodies.

Poster by Raffaella Faggioni, Director, Zhenling Yao, Meina Liang, Amy Schneider, Inna Vainshtein, Rozanne Lee and Lorin Roskos on the effect of the YTE mutation on the PK/PD of Medi5117.

Ziping Wei, fellow will present on the comparability assessment of biopharmaceutical products: strategy and practice.